COG2

Across TCGA cell cohorts, COG2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COG2-associated genes across cancer lineages are OR2A12, GLRA4, and GFRA4. Each is linked with COG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG2-to-partner and partner-to-COG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A12 grouped by COG2-low versus COG2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG2→partner) and Y-score (partner→COG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2A12 →	+0.006	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	GLRA4 →	+0.198	+4.544	<.001	.003	3	1
BLOOD_Leukemia	GFRA4 →	+0.203	+3.824	.008	.001	3	1
BLOOD_Leukemia	PRAC1 →	+0.550	+3.884	.006	.003	3	1
BLOOD_Leukemia	CCKAR →	+0.030	+3.824	<.001	.001	3	1
BLOOD_Leukemia	DCLK3 →	+0.300	+4.091	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR2A12 by COG2 expression — BLOOD_Myeloma

Explore this box plot interactively →