COG1

Across TCGA pan-cancer cohorts, COG1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COG1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COG1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where COG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	54	view →
UCEC	DFS	Quartile	All	0.983	0.758	.005	28	view →
PDAC	OS	Median	IV	0.381	0.951	.006	18	view →
LUAD	OS	Median	III,IV	0.879	0.285	.001	14	view →
LSCC	DFS	Median	II,III,IV	0.653	0.899	.018	13	view →
GBM	DFS	Tertile	All	0.657	0.939	<.001	9	view →
CCRCC	DFS	Quartile	III,IV	0.279	0.972	.001	8	view →
HNSC	DFS	Quartile	III,IV	0.906	1.000	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

COG1–COAD (DFS)

Open the COAD breakdown →