COG1

Across TCGA patient cohorts, COG1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,590 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COG1-associated genes across cancer lineages are DNAJC3, COG3, and NASP. Each is linked with COG1 in more than 5 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COG1 versus DNAJC3 in UCEC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJC3 →	+0.593	+0.299	<.001	<.001	3	6
BRCA	COG3 →	+0.665	+0.334	<.001	<.001	3	6
BRCA	NASP →	-0.931	-0.370	<.001	<.001	3	6
BRCA	VWA8 →	+0.707	+0.326	<.001	<.001	3	5
OV	CAND2 →	-0.625	-0.219	.001	.001	3	5
OV	TMEM219 →	+0.666	+0.283	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,590 associations by consensus.

COG1 vs DNAJC3 — UCEC

Explore this scatter interactively →