COG1

Across TCGA patient cohorts, COG1 mutation is significantly associated with the RNA expression of many other genes, with 1,568 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG1-associated genes across cancer lineages are NDUFAF1, BAG3, and CHAF1B. Each is linked with COG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF1 grouped by COG1-low versus COG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF1 →	+0.375	+2.470	.003	<.001	3	3
UCEC	BAG3 →	+0.610	+2.070	<.001	.001	3	2
UCEC	CHAF1B →	+0.631	+3.807	<.001	<.001	3	2
UCEC	CTLA4 →	+0.707	+2.337	.001	.003	3	2
UCEC	COX18 →	+0.390	+1.736	.002	.007	3	2
UCEC	SLBP →	+0.451	+3.732	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,568 associations by consensus.

NDUFAF1 by COG1 expression — UCEC

Explore this box plot interactively →