COG1

Across TCGA patient cohorts, COG1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG1-associated genes across cancer lineages are C-Raf, MEK1, and eIF4E. Each is linked with COG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by COG1-low versus COG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.196	+2.815	.014	.036	3	3
UCEC	MEK1 →	+0.425	+1.678	.001	.021	3	2
UCEC	eIF4E →	+0.165	+2.335	.037	.018	3	1
UCEC	ERK2 →	+0.166	+1.765	.021	.014	2	2
UCEC	ACC_pS79 →	+0.296	+1.874	.022	.049	3	1
UCEC	JNK2 →	+0.184	+2.196	.013	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

C-Raf by COG1 expression — COAD

Explore this box plot interactively →