COG1

Across TCGA cell cohorts, COG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,896 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COG1-associated GO terms across cancer lineages are Positive regulation of protein localization to mitochondrion, Process utilizing autophagic mechanism, and Autophagy. Each is linked with COG1 in more than 13 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to mitochondrion grouped by COG1-low versus COG1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of protein localization to mitochondrion →	+0.099	+0.616	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Process utilizing autophagic mechanism →	+0.067	+0.646	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Autophagy →	+0.067	+0.646	<.001	<.001	3	14
BREAST	Endosomal transport →	+0.052	+0.752	.002	<.001	3	14
BREAST	Cytosolic transport →	+0.064	+0.594	.003	.007	3	14
LUNG_NSCLC_LUSC	Macroautophagy →	+0.073	+0.677	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,896 associations by consensus.

Positive regulation of protein localization to mitochondrion by COG1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →