COG1

Across TCGA cell cohorts, COG1 mutation is significantly associated with the mutation status of many other genes, with 3,426 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COG1-associated genes across cancer lineages are ASH1L, EIF5B, and NIPBL. Each is linked with COG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASH1L grouped by COG1-low versus COG1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASH1L →	+2.399	+2.962	.002	.002	1	5
BLOOD_Lymphoma	EIF5B →	+4.584	+4.584	.007	.007	1	4
BLOOD_Leukemia	NIPBL →	+3.341	+3.341	.001	.001	1	4
BLOOD_Leukemia	ZNF608 →	+3.399	+3.669	<.001	<.001	1	4
BLOOD_Leukemia	IRS1 →	+2.984	+3.402	<.001	<.001	1	4
BLOOD_Lymphoma	ZBTB4 →	+4.584	+5.554	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,426 associations by consensus.

ASH1L by COG1 expression — BLOOD_Leukemia

Explore this box plot interactively →