COBLL1

Across TCGA patient cohorts, COBLL1 mutation is significantly associated with the RNA expression of many other genes, with 3,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COBLL1-associated genes across cancer lineages are MIR549A, PGAM5, and POLR2A. Each is linked with COBLL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COBLL1-to-partner and partner-to-COBLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR549A grouped by COBLL1-low versus COBLL1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBLL1→partner) and Y-score (partner→COBLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR549A →	+1.161	+5.653	<.001	.003	3	3
UCEC	PGAM5 →	+0.429	+1.669	<.001	<.001	3	3
UCEC	POLR2A →	+0.458	+1.643	.001	.002	3	3
UCEC	KMT5A →	+0.354	+1.680	<.001	<.001	3	3
UCEC	NF2 →	+0.457	+1.879	<.001	<.001	3	3
UCEC	TMEM201 →	+0.287	+1.617	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,391 associations by consensus.

MIR549A by COBLL1 expression — READ

Explore this box plot interactively →