COA7

Across TCGA pan-cancer cohorts, COA7 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COA7 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher COA7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COA7 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LIHC, KIRP, and ACC are the cancer types where COA7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.455	0.626	<.001	77	view →
KIRP	DFS	Quartile	All	0.588	0.902	<.001	66	view →
ACC	DFS	Quartile	All	0.162	0.749	<.001	51	view →
KIRC	DFS	Tertile	All	0.721	0.541	<.001	50	view →
LGG	OS	Median	All	0.393	0.520	<.001	39	view →
READ	DFS	Quartile	II,III,IV	1.000	0.244	.004	35	view →
UCEC	DFS	Median	All	0.576	0.685	<.001	28	view →
LUAD	OS	Median	All	0.778	0.886	.004	27	view →
SARC	OS	Tertile	All	0.355	0.647	<.001	27	view →
GBM	DFS	Median	All	0.393	0.187	.001	24	view →
STAD	OS	Quartile	All	0.746	0.547	.004	21	view →
LAML	DFS	Quartile	All	0.230	0.590	.019	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

COA7–LIHC (DFS)

Open the LIHC breakdown →