COA7

Across TCGA pan-cancer cohorts, COA7 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of COA7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COA7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COA7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where COA7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COA7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.173	<.001	12	view →
BLCA	Male	III,IV	+0.958	<.001	12	view →
STAD	Male	II,III,IV	+1.421	<.001	10	view →
LIHC	Male	II,III,IV	+1.110	<.001	9	view →
THCA	All	IV	−0.985	<.001	9	view →
LUAD	Male	All	+0.895	<.001	9	view →
LUSC	Male	III,IV	+1.640	<.001	8	view →
KICH	Female	II,III,IV	−1.244	<.001	7	view →
UCEC	All	II,III,IV	+0.746	.009	6	view →
KIRC	Male	All	−0.393	<.001	6	view →
ESCA	All	All	+0.783	.037	4	view →
COAD	Male	All	+0.431	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

COA7–HNSC

Open the HNSC breakdown →