COA7

Across TCGA pan-cancer cohorts, COA7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COA7 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COA7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COA7 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, COAD, and HNSC are the cancer types where COA7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.973	0.862	<.001	66	view →
COAD	DFS	Median	II,III,IV	1.000	0.882	.021	42	view →
HNSC	DFS	Median	III,IV	0.906	1.000	.006	11	view →
CCRCC	OS	Tertile	All	0.909	0.725	.022	9	view →
PDAC	DFS	Tertile	IV	0.726	0.199	.024	6	view →
LSCC	DFS	Median	II,III,IV	0.819	0.557	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COA7–LUAD (DFS)

Open the LUAD breakdown →