COA6

Across TCGA patient cohorts, COA6 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COA6-associated genes across cancer lineages are RNU6-1242P, NPM1P10, and LINC02131. Each is linked with COA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COA6-to-partner and partner-to-COA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1242P grouped by COA6-low versus COA6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA6→partner) and Y-score (partner→COA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1242P →	+1.096	+5.017	<.001	.009	3	1
COAD	NPM1P10 →	+0.210	+5.435	<.001	.005	3	1
COAD	LINC02131 →	+0.315	+5.516	<.001	.004	3	1
COAD	LINC01903 →	+0.219	+5.212	<.001	.007	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	MIR4268 →	+0.472	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

RNU6-1242P by COA6 expression — COAD

Explore this box plot interactively →