COA4

Across TCGA patient cohorts, COA4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,533 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COA4-associated proteins across cancer lineages are POLD2, POLD1, and POLD3. Each is linked with COA4 in more than 6 cancer types. Because this analysis shows association rather than direction, both COA4-to-partner and partner-to-COA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COA4 versus POLD2 in HNSC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COA4→partner) and Y-score (partner→COA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POLD2 →	+0.364	+1.099	<.001	<.001	3	7
LSCC	POLD1 →	+0.346	+0.449	<.001	<.001	3	6
LSCC	POLD3 →	+0.453	+0.594	<.001	<.001	3	6
LSCC	TK1 →	+0.659	+0.538	<.001	<.001	3	6
LSCC	NUMA1 →	+0.609	+0.809	<.001	<.001	3	5
LSCC	PAK1 →	+0.468	+0.641	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,533 associations by consensus.

COA4 vs POLD2 — HNSC

Explore this scatter interactively →