COA4

Across TCGA pan-cancer cohorts, COA4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated COA4 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COA4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COA4 expression acts as an unfavorable survival marker, although some lineages such as OV and MESO show a favorable association.

UVM, KICH, and ACC are the cancer types where COA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.412	0.755	<.001	130	view →
KICH	OS	Median	All	0.724	1.000	<.001	94	view →
ACC	DFS	Tertile	All	0.205	0.702	<.001	75	view →
HNSC	DFS	Median	All	0.230	0.471	<.001	69	view →
PAAD	DFS	Median	All	0.204	0.379	<.001	58	view →
LIHC	OS	Median	All	0.714	0.835	<.001	51	view →
OV	OS	Median	II,III,IV	0.376	0.275	.008	48	view →
KIRP	DFS	Tertile	All	0.829	0.960	.001	42	view →
MESO	DFS	Median	All	0.475	0.306	.013	24	view →
PRAD	DFS	Tertile	All	0.886	0.961	.002	18	view →
COAD	DFS	Median	IV	0.376	0.578	.020	17	view →
LUAD	OS	Median	All	0.317	0.403	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

COA4–UVM (DFS)

Open the UVM breakdown →