COA4

Across TCGA patient cohorts, COA4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,767 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COA4-associated genes across cancer lineages are ID1, CLNS1A, and CRISPLD2. Each is linked with COA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both COA4-to-partner and partner-to-COA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COA4 versus ID1 in LUAD, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA4→partner) and Y-score (partner→COA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ID1 →	-1.349	-0.434	<.001	<.001	3	4
BRCA	CLNS1A →	+0.465	+0.476	.005	<.001	3	4
OV	CRISPLD2 →	-0.990	-0.607	.001	<.001	3	4
OV	TPM4 →	-0.685	-0.735	.002	.002	3	4
OV	PXDC1 →	-0.744	-0.713	<.001	<.001	3	4
OV	SLC7A6OS →	-0.330	-0.615	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,767 associations by consensus.

COA4 vs ID1 — LUAD

Explore this scatter interactively →