COA4

Across TCGA cell cohorts, COA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,365 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COA4-associated GO terms across cancer lineages are Asparaginyl-tRNA aminoacylation, tRNA pseudouridine synthesis, and Mitochondrial respiratory chain complex III assembly. Each is linked with COA4 in more than 12 cancer types. Because this analysis shows association rather than direction, both COA4-to-partner and partner-to-COA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Asparaginyl-tRNA aminoacylation grouped by COA4-low versus COA4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COA4→partner) and Y-score (partner→COA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Asparaginyl-tRNA aminoacylation →	+0.206	+1.097	<.001	<.001	3	13
BONE	tRNA pseudouridine synthesis →	+0.089	+0.575	.004	.008	2	12
BONE	Mitochondrial respiratory chain complex III assembly →	+0.108	+0.630	.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Maintenance of Golgi location →	+0.088	+0.847	<.001	<.001	3	9
BLOOD_Lymphoma	Pseudouridine synthesis →	+0.064	+0.485	<.001	<.001	3	9
BLOOD_Lymphoma	mRNA pseudouridine synthesis →	+0.070	+0.538	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,365 associations by consensus.

Asparaginyl-tRNA aminoacylation by COA4 expression — OESOPHAGUS

Explore this box plot interactively →