CNTRL

Across TCGA patient cohorts, CNTRL mutation is significantly associated with the RNA expression of many other genes, with 5,235 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTRL-associated genes across cancer lineages are PSMC3IP, CHAC1, and SEC13. Each is linked with CNTRL in more than 4 cancer types. Because this analysis shows association rather than direction, both CNTRL-to-partner and partner-to-CNTRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by CNTRL-low versus CNTRL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTRL→partner) and Y-score (partner→CNTRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMC3IP →	+0.598	+2.615	<.001	.005	3	5
UCEC	CHAC1 →	+0.641	+1.908	<.001	<.001	3	5
UCEC	SEC13 →	+0.378	+1.736	<.001	<.001	3	4
UCEC	MRPL17 →	+0.260	+1.959	<.001	<.001	3	4
UCEC	POC1A →	+0.461	+1.440	<.001	<.001	3	4
UCEC	STOML2 →	+0.293	+1.879	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,235 associations by consensus.

PSMC3IP by CNTRL expression — COAD

Explore this box plot interactively →