CNTRL

Across TCGA pan-cancer cohorts, CNTRL RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CNTRL data layer compared with 12 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CNTRL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CNTRL expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

ACC, BRCA, and LGG are the cancer types where CNTRL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.770	0.967	<.001	111	view →
BRCA	OS	Tertile	All	0.949	0.891	.001	57	view →
LGG	DFS	Median	All	0.635	0.842	<.001	54	view →
SCLC	DFS	Tertile	II,III,IV	0.622	0.250	.001	42	view →
KIRC	DFS	Quartile	III,IV	0.469	0.737	.002	31	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
GBM	OS	Median	All	0.559	0.271	<.001	24	view →
HNSC	DFS	Quartile	IV	0.808	0.580	.003	22	view →
COAD	DFS	Median	All	0.742	0.818	.013	22	view →
KIRP	DFS	Quartile	All	0.766	0.941	.004	20	view →
CHOL	DFS	Median	II,III,IV	0.648	0.107	.006	14	view →
LIHC	DFS	Median	All	0.328	0.521	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CNTRL–ACC (OS)

Open the ACC breakdown →