CNTRL

Across TCGA patient cohorts, CNTRL mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTRL-associated genes across cancer lineages are Rad50, ATM, and Cyclin-B1. Each is linked with CNTRL in more than 3 cancer types. Because this analysis shows association rather than direction, both CNTRL-to-partner and partner-to-CNTRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CNTRL-low versus CNTRL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTRL→partner) and Y-score (partner→CNTRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Rad50 →	-0.260	-2.974	.010	.035	3	4
UCEC	ATM →	-0.427	-1.807	<.001	.003	3	4
UCEC	Cyclin-B1 →	+0.400	+1.917	.009	<.001	3	3
COAD	ASNS →	+0.809	+2.459	<.001	.017	3	3
LUSC	YB-1_pS102 →	+0.306	+2.871	<.001	.033	3	2
STAD	STAT3_pY705 →	-0.299	-3.000	.007	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Rad50 by CNTRL expression — COAD

Explore this box plot interactively →