CNTRL

Across TCGA cell cohorts, CNTRL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,619 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CNTRL-associated GO terms across cancer lineages are Negative regulation of cell cycle G2/M phase transition, Microtubule cytoskeleton organization involved in mitosis, and Protein localization to chromosome. Each is linked with CNTRL in more than 16 cancer types. Because this analysis shows association rather than direction, both CNTRL-to-partner and partner-to-CNTRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle G2/M phase transition grouped by CNTRL-low versus CNTRL-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTRL→partner) and Y-score (partner→CNTRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of cell cycle G2/M phase transition →	+0.073	+1.219	<.001	<.001	3	17
SOFT_TISSUE	Microtubule cytoskeleton organization involved in mitosis →	+0.114	+1.375	<.001	<.001	3	17
OVARY	Protein localization to chromosome →	+0.098	+1.237	<.001	<.001	3	17
PANCREAS	Protein localization to cytoskeleton →	+0.090	+0.980	<.001	<.001	3	17
BLOOD_Myeloma	Spindle elongation →	+0.217	+0.880	.003	.001	3	17
BONE	Centrosome duplication →	+0.114	+1.095	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,619 associations by consensus.

Negative regulation of cell cycle G2/M phase transition by CNTRL expression — BLOOD_Lymphoma

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