CNTRL

Across TCGA cell cohorts, CNTRL mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTRL-associated genes across cancer lineages are SASS6, ATP1A4, and OR13D1. Each is linked with CNTRL in more than 2 cancer types. Because this analysis shows association rather than direction, both CNTRL-to-partner and partner-to-CNTRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SASS6 grouped by CNTRL-low versus CNTRL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTRL→partner) and Y-score (partner→CNTRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SASS6 →	+0.450	+2.459	.003	.006	3	3
SOFT_TISSUE	ATP1A4 →	+0.086	+3.938	.003	.005	3	2
SOFT_TISSUE	OR13D1 →	+0.020	+4.392	<.001	.004	3	2
SOFT_TISSUE	CXorf49B →	+0.793	+4.142	<.001	.003	3	2
PANCREAS	IL4 →	+0.099	+3.786	<.001	.004	3	2
CNS	IL31 →	+0.020	+4.566	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

SASS6 by CNTRL expression — LARGE_INTESTINE

Explore this box plot interactively →