CNTNAP3

Across TCGA patient cohorts, CNTNAP3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTNAP3-associated genes across cancer lineages are EGFR_pY1173, FoxM1, and mTOR_pS2448. Each is linked with CNTNAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTNAP3-to-partner and partner-to-CNTNAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CNTNAP3-low versus CNTNAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTNAP3→partner) and Y-score (partner→CNTNAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.052	+1.874	.045	.049	3	2
UCEC	FoxM1 →	+0.191	+1.716	.022	.003	3	2
UCEC	mTOR_pS2448 →	-0.140	-3.687	.003	.001	3	2
UCEC	Notch1 →	+0.221	+3.183	<.001	<.001	3	2
UCEC	P-Cadherin →	-0.106	-1.807	.023	.024	3	2
UCEC	ATM →	-0.721	-3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1173 by CNTNAP3 expression — UCEC

Explore this box plot interactively →