CNTNAP3

Across TCGA pan-cancer cohorts, CNTNAP3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CNTNAP3 data layer compared with 8 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CNTNAP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNTNAP3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

ACC, LUAD, and BLCA are the cancer types where CNTNAP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.337	0.739	<.001	75	view →
LUAD	OS	Median	III,IV	0.363	0.605	.001	61	view →
BLCA	OS	Quartile	All	0.531	0.712	.001	51	view →
KIRC	DFS	Tertile	All	0.780	0.488	.001	51	view →
THCA	OS	Tertile	All	0.870	0.979	.007	47	view →
HNSC	OS	Quartile	IV	0.454	0.899	.001	40	view →
SKCM	OS	Median	All	0.535	0.247	<.001	32	view →
KIRP	DFS	Tertile	II,III,IV	0.864	0.306	.008	28	view →
MESO	OS	Tertile	All	0.605	0.222	.012	20	view →
BRCA	OS	Tertile	III,IV	0.709	0.510	.013	17	view →
UVM	DFS	Median	All	0.577	0.845	.026	17	view →
PCPG	OS	Median	All	0.733	1.000	.021	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CNTNAP3–ACC (DFS)

Open the ACC breakdown →