CNTLN

Across TCGA pan-cancer cohorts, CNTLN Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CNTLN data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CNTLN Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CNTLN expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUSC, and LUAD are the cancer types where CNTLN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.421	<.001	36	view →
LUSC	OS	Median	III,IV	0.104	0.690	<.001	15	view →
LUAD	OS	Median	II,III,IV	0.257	0.693	<.001	15	view →
SKCM	OS	Median	All	0.179	0.781	<.001	9	view →
CESC	DFS	Median	IV	0.053	0.529	<.001	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CNTLN–UCEC (DFS)

Open the UCEC breakdown →