CNTLN

Across TCGA pan-cancer cohorts, CNTLN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CNTLN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CNTLN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNTLN is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

KIRP, HNSC, and KIRC are the cancer types where CNTLN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNTLN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.852	<.001	11	view →
HNSC	Male	II,III,IV	+0.759	<.001	11	view →
KIRC	Male	All	+0.547	<.001	11	view →
THCA	Female	II,III,IV	−0.738	<.001	10	view →
BLCA	Male	IV	−1.397	.003	4	view →
UCEC	All	All	−0.757	<.001	4	view →
LUAD	Female	II,III,IV	−0.521	.006	3	view →
BRCA	Female	All	−0.223	.004	3	view →
CHOL	All	All	−0.507	.001	2	view →
READ	Female	All	−0.948	.035	1	view →
LUSC	All	III,IV	−0.793	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CNTLN–KIRP

Open the KIRP breakdown →