CNTLN

Across TCGA patient cohorts, CNTLN protein abundance is significantly associated with the protein abundance of many other proteins, with 8,395 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CNTLN-associated proteins across cancer lineages are PKNOX1, CDH1, and AKAP1_S429. Each is linked with CNTLN in more than 2 cancer types. Because this analysis shows association rather than direction, both CNTLN-to-partner and partner-to-CNTLN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNTLN versus PKNOX1 in HNSC, with a Pearson correlation of 0.77.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTLN→partner) and Y-score (partner→CNTLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PKNOX1 →	+0.962	+1.925	<.001	.001	3	3
LUAD	CDH1 →	-0.438	-0.463	<.001	<.001	2	3
UCEC	AKAP1_S429 →	-0.927	-1.016	<.001	<.001	3	2
HNSC	RFC1_T110 →	-0.729	-1.425	.001	.003	3	2
HNSC	RPRD1B_S166 →	+0.628	+1.941	<.001	<.001	3	2
HNSC	USP34_S3406 →	-0.634	-1.770	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,395 associations by consensus.

CNTLN vs PKNOX1 — HNSC

Explore this scatter interactively →