CNTLN

Across TCGA patient cohorts, CNTLN mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTLN-associated genes across cancer lineages are PCNA, Cyclin-B1, and FOXO3a_pS318_S321. Each is linked with CNTLN in more than 3 cancer types. Because this analysis shows association rather than direction, both CNTLN-to-partner and partner-to-CNTLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CNTLN-low versus CNTLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTLN→partner) and Y-score (partner→CNTLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.196	+2.115	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.571	+2.137	<.001	<.001	3	3
BLCA	FOXO3a_pS318_S321 →	-0.136	-2.321	.037	.035	3	3
BRCA	4E-BP1 →	+0.537	+2.820	.007	.037	3	3
UCEC	Tuberin →	+0.223	+1.807	.002	.003	3	3
LUAD	PKC-delta_pS664 →	-0.196	-3.157	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

PCNA by CNTLN expression — UCEC

Explore this box plot interactively →