CNTLN

Across TCGA cell cohorts, CNTLN mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTLN-associated genes across cancer lineages are XAGE5, LMX1A, and VCX2. Each is linked with CNTLN in more than 2 cancer types. Because this analysis shows association rather than direction, both CNTLN-to-partner and partner-to-CNTLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by CNTLN-low versus CNTLN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTLN→partner) and Y-score (partner→CNTLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	XAGE5 →	+0.426	+4.058	<.001	.009	3	3
BLOOD_Lymphoma	LMX1A →	+0.025	+3.714	<.001	.006	3	2
OVARY	VCX2 →	+0.473	+3.807	<.001	.006	3	2
OESOPHAGUS	PROP1 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	OR2T8 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	PRAMEF20 →	+0.013	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

XAGE5 by CNTLN expression — BLOOD_Lymphoma

Explore this box plot interactively →