CNTLN

Across TCGA cell cohorts, CNTLN mutation is significantly associated with the mutation status of many other genes, with 3,919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTLN-associated genes across cancer lineages are MCF2, UBR4, and RGS22. Each is linked with CNTLN in more than 4 cancer types. Because this analysis shows association rather than direction, both CNTLN-to-partner and partner-to-CNTLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCF2 grouped by CNTLN-low versus CNTLN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTLN→partner) and Y-score (partner→CNTLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCF2 →	+2.956	+3.129	<.001	<.001	1	5
BLOOD_Lymphoma	UBR4 →	+2.752	+2.847	.005	.005	1	5
BLOOD_Lymphoma	RGS22 →	+3.922	+3.247	.004	.004	1	5
UPPER_AERODIGESTIVE_TRACT	HMCN1 →	+2.954	+4.247	.006	.006	1	5
LUNG_NSCLC_LUAD	MCM3AP →	+3.303	+3.478	.006	.006	1	5
UPPER_AERODIGESTIVE_TRACT	KMT2C →	+2.954	+4.247	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,919 associations by consensus.

MCF2 by CNTLN expression — LARGE_INTESTINE

Explore this box plot interactively →