CNST

Across TCGA pan-cancer cohorts, CNST mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CNST data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CNST mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CNST expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where CNST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.880	0.580	.002	9	view →
GBM	DFS	Median	All	0.815	0.629	.009	2	view →
CCRCC	DFS	Median	All	0.708	0.895	.011	2	view →
PDAC	OS	Median	III,IV	0.568	0.301	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CNST–LUAD (OS)

Open the LUAD breakdown →