CNST

Across TCGA patient cohorts, CNST mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNST-associated genes across cancer lineages are YAP_pS127, ATM, and Caspase-7-cleavedD198. Each is linked with CNST in more than 1 cancer types. Because this analysis shows association rather than direction, both CNST-to-partner and partner-to-CNST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP_pS127 grouped by CNST-low versus CNST-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNST→partner) and Y-score (partner→CNST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	YAP_pS127 →	-0.517	-3.000	.008	.036	3	2
UCEC	ATM →	-0.435	-1.247	.004	.045	3	2
UCEC	Caspase-7-cleavedD198 →	+0.463	+1.827	.022	.015	3	2
UCEC	Cyclin-B1 →	+0.556	+3.459	.003	.005	3	2
COAD	Tuberin →	-0.345	-2.991	.038	.036	3	2
SKCM	Chk2_pT68 →	+0.171	+2.182	.035	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

YAP_pS127 by CNST expression — LUAD

Explore this box plot interactively →