CNST

Across TCGA cell cohorts, CNST RNA expression is significantly associated with the go_rna of many other GO terms, with 3,694 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CNST-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of DNA recombination, and Positive regulation of TORC2 signaling. Each is linked with CNST in more than 13 cancer types. Because this analysis shows association rather than direction, both CNST-to-partner and partner-to-CNST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by CNST-low versus CNST-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNST→partner) and Y-score (partner→CNST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Epigenetic regulation of gene expression →	+0.071	+0.625	<.001	<.001	3	14
BLOOD_Lymphoma	Positive regulation of DNA recombination →	+0.082	+0.995	<.001	<.001	3	14
STOMACH	Positive regulation of TORC2 signaling →	+0.098	+0.655	.002	.001	3	13
STOMACH	Heterochromatin formation →	+0.081	+0.759	<.001	.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.083	+1.177	.003	.007	2	14
OESOPHAGUS	Establishment of protein localization to organelle →	+0.076	+0.742	.002	<.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,694 associations by consensus.

Epigenetic regulation of gene expression by CNST expression — LIVER

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