CNR1

Across TCGA patient cohorts, CNR1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNR1-associated genes across cancer lineages are PDCD4, MEK1_p_S217_S221, and FOXO3a_pS318_S321. Each is linked with CNR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNR1-to-partner and partner-to-CNR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CNR1-low versus CNR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNR1→partner) and Y-score (partner→CNR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.509	-2.000	<.001	.002	3	3
UCEC	MEK1_p_S217_S221 →	-0.169	-1.247	.033	.041	3	2
UCEC	FOXO3a_pS318_S321 →	-0.081	-1.054	.025	.043	3	2
UCEC	GSK-3_pS9 →	-0.231	-1.502	.049	.025	3	2
UCEC	PCNA →	+0.205	+1.392	.001	.017	3	2
UCEC	PKC-b-II_pS660 →	-0.177	-1.289	.028	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

PDCD4 by CNR1 expression — UCEC

Explore this box plot interactively →