CNR1

Across TCGA pan-cancer cohorts, CNR1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CNR1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CNR1 RNA is repressed in tumor relative to normal tissue. In most cancer types CNR1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and LUAD are the cancer types where CNR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.926	<.001	12	view →
LUSC	Female	II,III,IV	−2.195	<.001	9	view →
LUAD	Male	II,III,IV	−1.856	<.001	9	view →
HNSC	Male	All	−0.318	.001	8	view →
KIRP	All	All	+1.004	<.001	7	view →
BRCA	All	III,IV	−1.114	<.001	6	view →
UCEC	All	All	−1.012	<.001	6	view →
KIRC	Male	All	+0.632	<.001	6	view →
READ	All	All	−2.251	<.001	5	view →
LIHC	All	All	+0.358	<.001	4	view →
UCEC	All	IV	+0.799	.029	2	view →
STAD	All	All	−0.789	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CNR1–COAD

Open the COAD breakdown →