CNPY4

Across TCGA pan-cancer cohorts, CNPY4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CNPY4 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CNPY4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CNPY4 expression acts as an unfavorable survival marker.

HNSC, UCEC, and LSCC are the cancer types where CNPY4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.502	0.790	.005	47	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	36	view →
LSCC	OS	Quartile	All	0.620	0.984	<.001	36	view →
CCRCC	OS	Median	II,III,IV	0.454	1.000	.014	17	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CNPY4–HNSC (OS)

Open the HNSC breakdown →