CNP

Across TCGA pan-cancer cohorts, CNP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CNP data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CNP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CNP expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where CNP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	IV	0.067	1.000	.024	12	view →
LUAD	DFS	Quartile	III,IV	1.000	0.429	.021	10	view →
PDAC	OS	Median	All	0.274	0.509	.015	8	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
GBM	OS	Quartile	All	0.228	0.603	.009	4	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CNP–CCRCC (OS)

Open the CCRCC breakdown →