CNP

Across TCGA pan-cancer cohorts, CNP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CNP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CNP RNA is repressed in tumor relative to normal tissue. In most cancer types CNP is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where CNP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.684	<.001	11	view →
KIRC	Male	II,III,IV	−1.140	<.001	11	view →
LUAD	All	III,IV	+0.899	<.001	9	view →
HNSC	Male	All	+0.573	<.001	9	view →
LIHC	Female	II,III,IV	+1.154	<.001	8	view →
THCA	Male	All	+0.361	<.001	8	view →
LUSC	Female	II,III,IV	+1.261	<.001	7	view →
BRCA	Female	All	+0.247	.002	6	view →
CHOL	All	II,III,IV	+2.280	<.001	5	view →
STAD	Male	All	+0.765	.005	4	view →
BLCA	Female	All	+0.553	.015	4	view →
COAD	All	II,III,IV	+0.312	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CNP–KICH

Open the KICH breakdown →