CNP

Across TCGA cell cohorts, CNP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,625 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNP-associated GO terms across cancer lineages are Negative regulation of intracellular estrogen receptor signaling pathway, Regulation of glycolytic process through fructose-6-phosphate, and Negative regulation of glycolytic process through fructose-6-phosphate. Each is linked with CNP in more than 14 cancer types. Because this analysis shows association rather than direction, both CNP-to-partner and partner-to-CNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of intracellular estrogen receptor signaling pathway grouped by CNP-low versus CNP-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNP→partner) and Y-score (partner→CNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of intracellular estrogen receptor signaling pathway →	+0.164	+0.976	.001	.003	3	15
OESOPHAGUS	Regulation of glycolytic process through fructose-6-phosphate →	+0.111	+0.737	.009	.003	2	14
OESOPHAGUS	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.111	+0.737	.009	.003	2	14
UPPER_AERODIGESTIVE_TRACT	Cell division →	+0.064	+0.805	.001	.002	3	13
CNS	Interleukin-23-mediated signaling pathway →	+0.185	+1.037	<.001	<.001	3	13
BLOOD_Myeloma	Nucleocytoplasmic transport →	+0.079	+1.123	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,625 associations by consensus.

Negative regulation of intracellular estrogen receptor signaling pathway by CNP expression — KIDNEY

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