CNP

Across TCGA cell cohorts, CNP mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNP-associated genes across cancer lineages are TGM6, OR10T2, and OR10R2. Each is linked with CNP in more than 1 cancer types. Because this analysis shows association rather than direction, both CNP-to-partner and partner-to-CNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by CNP-low versus CNP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNP→partner) and Y-score (partner→CNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	OR10T2 →	+1.075	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.428	+4.551	<.001	.004	3	1
LARGE_INTESTINE	PPDPFL →	+0.034	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ASCL3 →	+0.137	+3.617	.004	.004	3	1
LARGE_INTESTINE	OR52K1 →	+0.010	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TGM6 by CNP expression — BLOOD_Leukemia

Explore this box plot interactively →