CNOT8

Across TCGA cell cohorts, CNOT8 mutation is significantly associated with the mutation status of many other genes, with 1,586 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNOT8-associated genes across cancer lineages are RBM5, SOAT1, and SEC61A1. Each is linked with CNOT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT8-to-partner and partner-to-CNOT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM5 grouped by CNOT8-low versus CNOT8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT8→partner) and Y-score (partner→CNOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RBM5 →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	SOAT1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	SEC61A1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	MAP2K4 →	+2.865	+4.217	.007	.007	1	2
LARGE_INTESTINE	FOSL2 →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	DHX32 →	+5.672	+5.672	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,586 associations by consensus.

RBM5 by CNOT8 expression — LARGE_INTESTINE

Explore this box plot interactively →