CNOT6L

Across TCGA patient cohorts, CNOT6L mutation is significantly associated with the RNA expression of many other genes, with 3,564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT6L-associated genes across cancer lineages are PIEZO1P1, RPS10-NUDT3, and PMS2P10. Each is linked with CNOT6L in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT6L-to-partner and partner-to-CNOT6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIEZO1P1 grouped by CNOT6L-low versus CNOT6L-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT6L→partner) and Y-score (partner→CNOT6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIEZO1P1 →	+0.194	+5.221	<.001	.003	3	3
UCEC	RPS10-NUDT3 →	+0.230	+1.906	<.001	<.001	3	2
UCEC	PMS2P10 →	+0.215	+2.024	.007	.005	3	2
LUSC	RNU6-1277P →	+0.336	+4.548	<.001	.009	3	2
CESC	MIR4510 →	+0.146	+3.927	<.001	.001	3	2
UCEC	CARS1 →	+0.455	+1.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,564 associations by consensus.

PIEZO1P1 by CNOT6L expression — HNSC

Explore this box plot interactively →