CNOT4

Across TCGA pan-cancer cohorts, CNOT4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CNOT4 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CNOT4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CNOT4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where CNOT4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	1.000	0.706	.007	15	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	3	view →
LUAD	OS	Quartile	III,IV	0.476	1.000	.031	3	view →
GBM	OS	Median	All	0.654	0.871	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CNOT4–PDAC (OS)

Open the PDAC breakdown →