CNOT4

Across TCGA pan-cancer cohorts, CNOT4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CNOT4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CNOT4 RNA is repressed in tumor relative to normal tissue. In most cancer types CNOT4 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where CNOT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNOT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.941	<.001	11	view →
HNSC	All	II,III,IV	+0.450	<.001	10	view →
LIHC	Male	All	+0.728	<.001	8	view →
CHOL	Male	All	+1.341	<.001	5	view →
LUSC	All	All	+0.204	.004	4	view →
KIRC	All	All	+0.187	.002	3	view →
READ	All	III,IV	+0.505	.036	2	view →
KIRP	All	IV	+0.472	.032	2	view →
UCEC	All	All	−0.457	.001	2	view →
ESCA	All	All	+0.442	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CNOT4–THCA

Open the THCA breakdown →