CNOT4

Across TCGA patient cohorts, CNOT4 mutation is significantly associated with the RNA expression of many other genes, with 4,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT4-associated genes across cancer lineages are TOMM22P5, SZRD1, and CCL4. Each is linked with CNOT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT4-to-partner and partner-to-CNOT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOMM22P5 grouped by CNOT4-low versus CNOT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT4→partner) and Y-score (partner→CNOT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOMM22P5 →	+0.170	+1.641	<.001	.001	3	3
UCEC	SZRD1 →	+0.373	+1.947	<.001	<.001	3	3
UCEC	CCL4 →	+0.589	+1.495	.005	.004	3	3
CESC	RNU1-17P →	+0.378	+5.103	<.001	.008	3	2
CESC	MIR920 →	+0.505	+5.539	<.001	.004	3	2
PRAD	RNU6-747P →	+0.324	+7.939	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,102 associations by consensus.

TOMM22P5 by CNOT4 expression — UCEC

Explore this box plot interactively →