CNOT4

Across TCGA patient cohorts, CNOT4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT4-associated genes across cancer lineages are eIF4E, FoxM1, and INPP4B. Each is linked with CNOT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT4-to-partner and partner-to-CNOT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CNOT4-low versus CNOT4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT4→partner) and Y-score (partner→CNOT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.257	+2.832	.008	.035	3	3
UCEC	FoxM1 →	+0.317	+2.523	<.001	<.001	3	2
UCEC	INPP4B →	-0.224	-2.700	.042	.005	3	2
COAD	PCNA →	+0.415	+2.820	.002	.035	3	2
UCEC	Stathmin →	+0.109	+1.247	.020	.045	3	2
COAD	Caspase-7-cleavedD198 →	+1.831	+2.815	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4E by CNOT4 expression — COAD

Explore this box plot interactively →