CNOT4

Across TCGA cell cohorts, CNOT4 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNOT4-associated genes across cancer lineages are GRM6, SSX7, and IQCF5. Each is linked with CNOT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT4-to-partner and partner-to-CNOT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM6 grouped by CNOT4-low versus CNOT4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT4→partner) and Y-score (partner→CNOT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GRM6 →	+0.037	+4.794	<.001	.001	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.633	+3.330	.001	.002	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.617	+3.451	.001	.002	3	1
LARGE_INTESTINE	FBXL4 →	+0.532	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

GRM6 by CNOT4 expression — STOMACH

Explore this box plot interactively →