CNOT3

Across TCGA patient cohorts, CNOT3 mutation is significantly associated with the RNA expression of many other genes, with 4,465 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT3-associated genes across cancer lineages are NCAPG, GMNN, and CCNB1. Each is linked with CNOT3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNOT3-to-partner and partner-to-CNOT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by CNOT3-low versus CNOT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT3→partner) and Y-score (partner→CNOT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	+0.699	+3.180	<.001	<.001	3	4
UCEC	GMNN →	+0.462	+2.000	.004	.008	3	4
UCEC	CCNB1 →	+0.504	+1.432	.004	.005	3	4
SKCM	CCNB2 →	+0.804	+3.208	.002	.009	3	4
UCEC	DONSON →	+0.399	+1.857	.001	<.001	3	4
UCEC	STRAP →	+0.441	+2.021	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,465 associations by consensus.

NCAPG by CNOT3 expression — UCEC

Explore this box plot interactively →