CNOT2

Across TCGA patient cohorts, CNOT2 mutation is significantly associated with the RNA expression of many other genes, with 3,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT2-associated genes across cancer lineages are MIR3196, TRAJ40, and RNA5SP239. Each is linked with CNOT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT2-to-partner and partner-to-CNOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3196 grouped by CNOT2-low versus CNOT2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT2→partner) and Y-score (partner→CNOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3196 →	+0.344	+4.986	<.001	.003	3	3
COAD	TRAJ40 →	+0.645	+3.622	.005	.002	3	3
STAD	RNA5SP239 →	+0.610	+4.139	<.001	.004	3	3
BRCA	OR10AE1P →	+0.020	+5.548	.002	.001	3	2
CESC	MIR103A1 →	+0.264	+5.579	<.001	.001	3	2
CESC	TRAJ52 →	+0.425	+4.384	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,053 associations by consensus.

MIR3196 by CNOT2 expression — BRCA

Explore this box plot interactively →