CNOT1

Across TCGA pan-cancer cohorts, CNOT1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CNOT1 data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CNOT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CNOT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and THCA are the cancer types where CNOT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.970	0.819	.001	36	view →
THCA	DFS	Median	All	0.095	0.896	<.001	18	view →
BLCA	DFS	Median	II,III,IV	0.607	0.319	.006	16	view →
LUSC	DFS	Median	All	1.000	0.749	.010	12	view →
ESCA	DFS	Median	II,III,IV	0.217	0.531	.011	12	view →
LUAD	DFS	Median	IV	0.333	0.671	.048	6	view →
HNSC	OS	Median	IV	0.210	0.641	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CNOT1–THYM (OS)

Open the THYM breakdown →