CNOT1

Across TCGA pan-cancer cohorts, CNOT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CNOT1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CNOT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CNOT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where CNOT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	1.000	0.290	.008	30	view →
PDAC	DFS	Tertile	III,IV	0.342	0.967	.001	24	view →
LUAD	DFS	Tertile	III,IV	0.962	0.311	.001	19	view →
CCRCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	6	view →
LSCC	OS	Median	All	0.830	0.928	.008	4	view →
HNSC	OS	Median	All	0.993	0.941	.028	3	view →
GBM	OS	Median	All	0.625	0.449	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CNOT1–UCEC (DFS)

Open the UCEC breakdown →